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This MOOC provides attendants with fundamental knowledge about the main challenges in modelling the energy transition at both global and regional levels, as well as the industrial ecology instruments to measure the associated impacts. The course begins by covering national energy accounting and the definition of a reference energy system, followed by an introduction to modelling for energy planning through linear programming. Participants will be engaged in hands-on practice using Excel. Additionally, scenario analysis principles are provided to help participants wisely discuss the results of practical case studies. Next, the course covers national economic accounting and the use of monetary input-output tables for national and multiregional applications, such as computing carbon footprints. Participants will also learn about Leontief鈥檚 production and impact model, which is demonstrated through another Excel-based hands-on session. Lastly, students will be introduced to the use of MARIO, an in-house, Python-based open-source tool for regional and multi-regional impact assessment studies based on Input-Output Analysis. By the end of the MOOC, participants will acquire a strong foundational knowledge for scientifically approaching the global energy transition; they will be able to understand and interpretate national economic and energy accounting tables, as well as to apply specific tools freely available to plan energy interventions and to assess their impacts.