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In this module, we will examine informatics as a potential methodology and resource to inform data-to-action initiatives. Lesson one will define key concepts including informatics, knowledge complexity, and knowledge management. Building on these concepts, we will investigate the levels of knowledge management proposed by Verna Allee. We will also consider the different perspectives on the proposed creation of a new social informatics specialty. Building on our understanding of knowledge management, in lesson two, we will explore knowledge representation structures. We will also analyze the use of publicly available population health records as contextual information to manage knowledge and data for action to reduce health disparities. In addition, we will evaluate knowledge representation structures of evidence-based social determinants of health interventions. Finally, we will explore some informatics applications including the Population Health Record and the WHO Health Equity Assessment Toolkit (HEAT).