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The course is a comprehensive set of didactic lectures surveying fundamentals of transgender medical and surgical treatment. The material is meant to provide the student with core knowledge that is essential for current primary care providers caring for transgender patients. There are 10 modules led by the expert clinical faculty from the pioneering Center for Transgender Medicine and Surgery, located within the Mount Sinai Health System and the Icahn School of Medicine at Mount Sinai in New York City. The course begins with an introduction to frame the sea change that has taken place in the current medical practice of transgender health care. Subsequent modules allow individuals to learn key elements necessary to provide quality transgender medical care. As a whole, the modules provide an opportunity to develop a knowledgeable approach to behavioral health, primary care, hormone therapy, and the surgical options. Module 1: Introduction - Joshua D Safer Module 2: Making the Determination - Hansel Arroyo Module 3: Primary Care for Transgender Women - Zil Goldstein Module 4: Primary Care for Transgender Men - Zil Goldstein Module 5: What are the Essential Strategies to Transgender Hormone Therapy? - Joshua D Safer Module 6: Initiation and Maintenance of Hormones for the Trans Masculine Patient - Joshua D Safer Module 7: Initiation and Maintenance of Hormones for the Trans Feminine Patient -Joshua D Safer Module 8: Transgender Surgery: Chest & Face - Bella K Avanessian Module 9: Transmasculine Genital Surgery - Bella K Avanessian Module 10: Transfeminine Genital Surgery - Bella K Avanessian