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This module introduces the healthcare ecosystem, focusing on its structure and the dynamics among the various constituents. The module begins with an overview of the healthcare system, highlighting significant issues, gaps, and emerging trends. It underscores the roles of various stakeholders, including physicians, nursing staff, hospitals, and the extensive supply chain, including pharmaceutical firms, biotech companies, medical device manufacturers, IT companies, regulators, and patients. The module addresses the relationship between healthcare spending and GDP growth, highlighting sustainability concerns and the difficulty in achieving multiple goals regarding cost, quality, and access. It discusses the demographic and policy challenges of the uninsured population in the U.S. It briefly reviews the changing healthcare ecosystem and invites learners to explore what is happening in other industries. By laying this foundational knowledge, the module prepares learners for a deeper exploration of the healthcare ecosystem's intricate and evolving landscape in subsequent modules.