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In this module, we will now focus our attention on the diffusion of pricing and prescription medications in the U.S. Prescription drugs account for over 10% of total healthcare spending in the U.S. and are increasingly important for managing chronic conditions. However, the regulatory process for approving new drugs has long been a source of controversy, with stakeholders contending it is inefficient and contributes to rising drug costs. To better understand these issues, we will explore how drugs are developed and regulated.We will also continue on in our exploration of initiatives addressing the cost and value of prescription drugs in this module. Rising drug costs have been a major concern for both the private and public sectors, with initiatives ranging from value-based contracts to federal and state laws aimed at negotiating drug prices and limiting out-of-pocket expenses for patients. While the impact of many of these initiatives is yet to be evaluated, the hope is that they will ultimately result in affordable access to prescription drugs for all Americans.